A glimpse of the possible future for chemical and energy vectors production, evidencing the change in the energy-chemistry nexus, refinery and chemical production, and priority targets, is presented. The aspects shortly discussed are the following: i) the energy-chemistry nexus, ii) moving to a new sustainable energy scenario, iii) energy storage: from smart grids to chemical storage of energy, iv) a new vision for refineries, v) CO2: a key carbon source element, vi) methanol: at the crossover of new energy-chemistry nexus, vii) exploiting shale-gas, viii) biogas-based chemistry and ix) solar-driven chemistry.